Objective: This study aimed to develop implementation strategies for colorectal cancer (CRC) surgical isolation techniques to reduce postoperative metastasis.Methods: Following PRISMA and the PIPOST model, 8 studies were included and 10 best evidence items were extracted.Results: A baseline audit at a Shanghai Grade 3A hospital (n=242 patients, 28 nurses, 13 surgeons) revealed compliance below 60% for 7 of 10 audit indicators (e.g., abdominal cavity flushing: 45.45%; intraoperative glove replacement: 45.87%), while two high-level evidence indicators achieved 100% compliance. Key barriers included insufficient training (65.70% compliance) and poor team communication. Facilitators included staff training willingness and adequate equipment.Conclusion: The study concludes with a multi-level strategy framework targeting system, practitioner, and patient factors to standardize practice and reduce iatrogenic metastasis.

Hailei Bian has completed her master's degree of nursing specialist in Tongji universitiy in 2024.She works in Shanghai East Hospital as the deputy head nurse of OR department. She has published more than 5 papers in reputed journals.