The ongoing healthcare transformation towards personalized, preventive, predictive, participative precision medicine (5PM) enables early identification, proactive intervention and full understanding of the course of disease, i.e., its pathology and its effective treatment. Thereby, it considers individual health status, conditions, genetic and genomic dispositions in personal social, occupational, environmental and behavioral context. The resulting health ecosystem is interdisciplinary, highly dynamic and complex, managed by experts from multiple knowledge and policy domains, deploying their methodologies, terminologies and ontologies at different levels of maturity, knowledge, skills and experiences. To enable communication and cooperation between all actors including the subject of care, their concepts have to be formally represented and interrelated. For that purpose, the author developed the ISO 23903 Interoperability and integration reference architecture – Model and framework, developed by the author, defines such approach. The solution is mandatory for any specification or project at ISO, CEN, IEEE, etc. addressing more than just one domain. The presented approach enables design, implementation and management of intelligent and ethical health and social care systems as well as knowledge-based communication and cooperation of all actors involved. Thereby, it manages also security, privacy and trust in detail. The Keynote introduces necessary standards and methodologies for designing and managing 5P medicine ecosystems as well as practical examples. The presented solution was also applied in many other domains, such as nursing education, nanotechnology, pharmaceutical R&D, astrophysics, environmental sciences, etc.

Dr. Bernd Blobel studied Mathematics, Technical Cybernetics and Electronics, Bio-Cybernetics, Physics, Medicine and Informatics at the University of Magdeburg and other universities in the former GDR. He received his PhD in Physics with a neurophysiological study. Furthermore, he performed the Habilitation (qualification as university professor) in Medicine and Informatics. He was Head of the Institute for Biometrics and Medical Informatics at the University of Magdeburg, and thereafter Head of the Health Telematics Project Group at the Fraunhofer IIS in Erlangen. Thereafter, he acted until his retirement as Head of the German National eHealth Competence Center as well as Head of the globally unique International Interdisciplinary PhD and PostDoc College at the University of Regensburg. He was and is still leadingly involved in many countries health digitalization as well as electronic health record strategy. He published more than 600 papers, published/edited many books and supervised a big number of PhD students from all around the world. He was German Representative to many SDOs such as HL7, ISO, CEN, OMG, IEEE, ASTM, SNOMED, etc., also chairing the national mirror groups. Furthermore, he still engaged in international higher education. He is Fellow of several international academies and played specific roles in global organizations such as WHO, European Commission, UNESCO, etc.