4th International Conference on
Neurology & Neurological Disorders
October 15–16, 2026 | Paris, France
Millennium Hotel Paris Charles De Gaulle
Address: Zone Hoteliere 2 Allee Du Verger Roissy En France, 95700, Paris, France
Address: Zone Hoteliere 2 Allee Du Verger Roissy En France, 95700, Paris, France
Neurology 2026
Birgit Deiman
Catharina Hospital, Netherlands
Title : The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke
Abstract:
Clopidogrel therapy is recommended to prevent recurrent ischemic stroke. However, clopidogrel resistance exists. This study examines which enzymes are involved in clopidogrel resistance. The study group includes 402 neurology patients who had experienced a recurrent ischemic stroke while receiving clopidogrel monotherapy. Patients were genotyped for CYP2C19, CYP2C9, CYP2B6, CYP3A4, CYP3A5, CYP1A2, ABCB1 and CES1A1. Phenotype frequencies were compared with those of a Global(G), European(E) and a local patient control(C) group. Only for ABCB1 a significant difference in phenotype distribution was seen (pG=0.003, pE=
Biography:
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