Tumor Microenvironment (TME)

Tumor Microenvironment (TME)

The tumor microenvironment (TME) is a dynamic and complex network of non-cancerous cells, signaling molecules, extracellular matrix components, and blood vessels surrounding a tumor. Understanding the TME is critical as it plays a decisive role in tumor initiation, progression, metastasis, and response to therapy. The interactions between cancer cells and stromal cells, immune cells, fibroblasts, and endothelial cells can either promote tumor growth or suppress it, making the TME a key therapeutic target. Research in TME focuses on elucidating mechanisms of immune evasion, angiogenesis, and metabolic adaptation. This session will explore strategies to modulate the TME, including immunotherapy, stromal targeting, and microenvironment normalization, which can enhance treatment efficacy and patient outcomes.

·         Components of the TME: immune cells, fibroblasts, ECM, vasculature

·         TME in tumor progression and metastasis

·         Immune evasion and immunosuppressive mechanisms

·         Therapeutic targeting of TME: immunotherapy and stromal modulation

·         TME and resistance to chemotherapy and radiotherapy

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