Pyrazoles and pyrazolo fused pyridines and pyrimidines are well known for their applications in the various fields like pharmaceuticals, agrochemicals and materials sciences. The diverse biological activities of pyrazoles make them valuable tools in drug discovery, agriculture, and biomedical research. Here, we have developed an atom economical chemo- and regio-selective reaction method for the synthesis of the biological important pyrazole derivatives from acetophenones and hydrazine or 3-aminopyrazole under acidic and basic conditions taking their applications under account. The acidic condition yields the pyrazolo-pyridine compounds while in alkaline medium, pyrazolo-pyrimidines were obtained in good to excellent yields. Bis-pyrazole derivative is also effectively produced under the same reaction conditions. The selectivity of the reaction can easily be tuned by shifting reaction from acidic to basic medium for the synthesis of pyrazolo-pyrirmidines and pyrazolo-pyridines respectively. The reaction shows excellent functional group tolerance in the form of -F, -Cl, -Br, -NMe2, -OH, -OMe, and -B(OH)2 in good yields.

Dr. Poonam Kumari is Wise-Pdf, Department of Chemistry, ARSD College, University of Delhi. She has completed her PhD at the age of 32 years from Delhi University and postdoctoral studies from ARSD College, Delhi University. She has teaching experience of about 6 years. She has published 11 research papers in various international and national journals. She has delivered oral/poster presentations in international and national conferences/workshops. Currently she is working at ARSD College, University of Delhi as a Women Scientist (WISE-PDF). Her research work mainly focused on the synthesis of fluorinated Heterocycles based natural products.