Evidence-based practice (EBP) is universally recognized as integral to enhancing healthcare quality and patient outcomes. It integrates current medical literature, clinical expertise, and patient preferences to solve problems. While nursing research generates new knowledge and EBP employs existing evidence in practice, a growing number of studies aim to bridge this gap effectively. EBP empowers nurses as agents of change, providing tools to optimize healthcare outcomes. By linking medical knowledge with practical experience, nurses using EBP can standardize care, reduce errors, and positively impact patients, communities, and the global healthcare landscape. This approach empowers nurses to transform healthcare delivery, ensuring better care and improved results.