Health and social care systems around the world undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions in personal, social, occupational, environmental and behavioral context from the perspective of multiple domains. For enabling communication and cooperation between actors from different domains using different methodologies, languages and ontologies based on different education, experiences, etc., we have to advance design and management of the resulting complex and highly dynamic ecosystem from data to knowledge level. The challenge is the consistent, correct and formalized representation of the transformed health ecosystem use-case specifically from the perspectives of all domains involved including the legal and ethical ones, representing and managing them based on related ontologies. The resulting business view of the real-world ecosystem must be interrelated using the ISO/IEC 21838 Top Level Ontologies standard. Thereafter, the outcome can be transformed into implementable solutions. The different viewpoints are represented using viewpoint-specific ICT ontologies, thereby extending the views defined in ISO/IWC 10746 through the real-world business view. The solution is a system-oriented, architecture-centric, ontology-based, policy-driven, interdisciplinary ecosystem design and management approach as standardized in ISO 23903 Health informatics - Interoperability and Integration Reference Architecture, developed by the author. For any use-case, comprehensive communication and cooperation between all actors and systems through mutual understanding by knowledge system mapping, but also the correct adaption of any system component in any viewpoint such as for re-using standards, specifications and products, is enabled. Following the proposed model and framework, we can enable integration and interoperability between any ecosystem component as well as communication and cooperation between all actors from all domains including the subject of care, but also between any existing ICT component.

Prof. Blobel studied Mathematics, Technical Cybernetics and Electronics, Theoretical Physics, Biocybernetics, Informatics, and Medicine at different universities in East Germany. He received the PhD degree in Physics with the PhD thesis “About the mechanism of information processing and energy transformation in bioreceptors – a general and membrane structure related transducer model”. Furthermore, he received a habilitation in Medicine with a postdoctoral thesis “Implications of physical environmental factors on health”, and a habilitation in Medical Informatics with a postdoctoral thesis “Analysis and Design for Secure and Interoperable Distributed Health Information Systems”. He was Head of the Physical Laboratory in Environmental Medicine at the Medical University Magdeburg and thereafter Head of the Medical Informatics Department and then Director of the Institute for Biometrics and Medical Informatics at the Medical Faculty of the Otto-von-Guericke University Magdeburg. In 2004, he became Founder and Head of the Health Telematics Project Group at Fraunhofer Society, Institute of Integrated Circuits (IIS), Erlangen, and thereafter Head of the German National eHealth Competence Center (eHCC) and Head of the globally unique International Interdisciplinary PhD and PostDoc College at the University of Regensburg. He is the author of more than 600 scientific publications.