Background: Platelet-rich plasma (PRP), a platelet-concentrated blood derivative obtained through centrifugation, has been investigated for ovarian rejuvenation since 2017, though its clinical efficacy remains controversial.

Objective: This study assessed the effect of autologous PRP on anti-Müllerian hormone (AMH) levels in women with diminished ovarian reserve undergoing in vitro fertilization (IVF) at Hanoi Obstetrics and Gynecology Hospital from August 2024 to February 2025.
Methods: An interventional study was conducted on 28 women with AMH < 2 ng/mL undergoing IVF during the study period. Changes in AMH levels after intraovarian PRP administration were analyzed, and outcomes were compared according to age and antral follicle count (AFC).
Results: After PRP treatment, AMH levels increased in 75% of patients, remained unchanged in 3.57%, and decreased in 21.43%. A significantly higher rate of AMH improvement was observed in women under 40 years of age compared with those aged 40 years or older (p < 0.05). No statistically significant difference in PRP effectiveness was found between patients with AFC < 5 and those with AFC ≥ 5 (p > 0.05).
Conclusion: Intraovarian PRP injection appears to have a positive effect on AMH levels in women with diminished ovarian reserve undergoing IVF, particularly in younger patients.

Binh Vu Thanh has completed his PhD at the age of 24 years from Vietnam Military Medical University and postdoctoral studies from Hanoi Medical University. He is a doctor from Department of Assisted Reproductive and Andrology