Cancer metabolism and therapeutic targeting
Cancer metabolism refers to the alterations in cellular metabolism that occur in cancer cells, which allow them to proliferate and survive under adverse conditions. Cancer cells have unique metabolic profiles compared to normal cells, and this has led to the development of novel therapeutic strategies targeting cancer metabolism.
In recent years, there has been increasing interest in targeting cancer metabolism as a way to develop new cancer treatments. Researchers have identified several key metabolic pathways that are altered in cancer cells, such as the Warburg effect, which describes the increased glycolytic activity of cancer cells.
Therapeutic targeting of cancer metabolism involves identifying and developing drugs that can inhibit these metabolic pathways, with the goal of inducing cancer cell death. Some of the most promising targets include enzymes involved in glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle.
Advancements in cancer metabolism research have led to the development of several new drugs that are currently undergoing clinical trials. For example, some drugs that inhibit enzymes involved in the pentose phosphate pathway are being tested in clinical trials for the treatment of acute myeloid leukemia.
Overall, cancer metabolism is an exciting and rapidly evolving field of cancer research, with the potential to identify new targets for cancer therapy and improve patient outcomes.