Adeno-associated virus (AAV) is a non-enveloped DNA virus infecting a wide variety of species, tissues and cell types, which is recognized as safe and effective method for delivering therapeutic transgenes. AAV vector is the most popular viral gene delivery system in clinical delivery system with unique and multiple advantages, such as tissue tropism, transduction specificity, long-lasting gene expression, low immune responses, without host chromosome incorporation. Till now, four AAV-based gene therapy drugs have already been approved by the US Food and Drug Administration (FDA) or European Medicines Agency (EMA). As the most devastating diseases in the world, in the U.S. alone more than 1.5 million cancer cases are diagnosed each year with relative 5-year survival rate of 68% according to the Centers for Disease Control and Prevention (CDC). Due to the characteristics of high transferring ability, low host immune response, and long-term gene expression, in combination with several technologies (miRNA, ICI, ACT), AAV have been successfully used for cancer gene therapy to deliver and transfer therapeutic genes (suicide genes, anti-angiogenic genes, and immune-related genes) to cancer cells for inhibiting tumor initiation, growth, and metastasis. The study investigates the potential of manipulating AAV vectors in preclinical applications and clinical translation, which emphasizes the challenges and prospects in viral vector selection, drug delivery strategies, immune reactions in cancer immunotherapy. 

My career focuses on virology, gene therapy, oncology, and immunology. I get Global Recognition Awards based on my contributions to scientific research. I serve as academic book/journal editor for Cancer Treatment and Survivorship, Annals of Urology, The European Journal of Cancer, The Journal of Clinical Microbiology, The Journal of Hypertension, Molecular & Cellular Biomechanics, Frontiers in Immunology, Current Advances in Medicine. I also serve as the International Science and Engineering Fair (ISEF) grand award judge in Plant Sciences, Animal Sciences, Microbiology, Biomedical and Health Sciences. I review manuscripts in more than 20 academic journals.